Skip to main content

Table 2 Enrichment estimates of eQTLs for childhood onset asthma GWAS SNPs from six tissues. Significant P values after FDR correction are shown in bolded type (FDR ≤ 0.05)

From: Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus

Tissue

GWAS threshold

OR

P

Padj

N

NeSNP

Adrenal

1.0 × 10−5

1.31

2.2 × 10−1

4.7 × 10−1

175

588,348

 

1.0 × 10−6

1.00

9.9 × 10−1

9.9 × 10−1

  
 

1.0 × 10−7

0.75

4.2 × 10−1

5.3 × 10−1

  
 

1.0 × 10−8

1.04

9.1 × 10−1

9.5 × 10−1

  

Brain—frontal cortex

1.0 × 10−5

1.71

2.4 × 10−2

9.6 × 10−2

118

367,312

 

1.0 × 10−6

1.32

3.6 × 10−1

5.2 × 10−1

  
 

1.0 × 10−7

1.23

5.7 × 10−1

6.8 × 10−1

  
 

1.0 × 10−8

1.46

3.4 × 10−1

5.2 × 10−1

  

Brain—hypothalamus

1.0 × 10−5

2.25

1.2 × 10−3

9.7 × 10−3

108

251,506

 

1.0 × 10−6

1.70

1.1 × 10−1

2.8 × 10−1

  
 

1.0 × 10−7

1.68

1.8 × 10−1

4.3 × 10−1

  
 

1.0 × 10−8

1.62

2.7 × 10−1

4.9 × 10−1

  

Ovary

1.0 × 10−5

1.65

5.5 × 10−2

1.8 × 10−1

122

292,461

 

1.0 × 10−6

1.34

3.7 × 10−1

5.2 × 10−1

  
 

1.0 × 10−7

0.94

8.9 × 10−1

9.5 × 10−1

  
 

1.0 × 10−8

0.80

6.8 × 10−1

7.8 × 10−1

  

Testis

1.0 × 10−5

0.80

2.4 × 10−1

4.8 × 10−1

225

1,358,512

 

1.0 × 10−6

0.69

1.0 × 10−1

2.8 × 10−1

  
 

1.0 × 10−7

0.80

4.1 × 10−1

5.3 × 10−1

  
 

1.0 × 10−8

0.75

3.3 × 10−1

5.2 × 10−1

  

Airway epithelial cells

1.0 × 10−5

3.68

2.8 × 10−5

6.8 × 10−4

104

185,407

 

1.0 × 10−6

3.28

2.8 × 10−3

1.7 × 10−2

  
 

1.0 × 10−7

4.11

8.9 × 10−4

9.7 × 10−3

  
 

1.0 × 10−8

3.91

6.2 × 10−3

2.7 × 10−2

 Â