Table 4 Mendelian randomization results of gene expression and DNA methylation identified from colocalization triplets. We considered the relationship between DNA methylation and gene expression to be causal if the adjusted P value ≤ 0.05
SNP | SNP Position (Chr:Pos) | CpG | Gene | Vehicle | RV | ||
|---|---|---|---|---|---|---|---|
P | Padj | P | Padj | ||||
rs34372395 | 1:152167407 | cg15025200 | FLG-AS1 | < 1.0 × 10−3 | <  1.2 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs34372395 | 1:152167407 | cg23107878 | FLG-AS1 | 1.0 × 10−3 | 1.2 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs1552994 | 1:152171461 | cg09127314 | FLG-AS1 | <  1.0 × 10−3 | <  1.2 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs1552994 | 1:152171461 | cg21280320 | FLG-AS1 | <  1.0 × 10−3 | <  1.2 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs1552994 | 1:152171461 | cg02754945 | FLG-AS1 | 1.0 × 10−3 | 1.8 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs1552994 | 1:152171461 | cg26320663 | FLG-AS1 | 1.0 × 10−3 | 1.8 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs1552994 | 1:152171461 | cg13498757 | FLG-AS1 | 2.0 × 10−3 | 3.1 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs7545406 | 1:152193286 | cg26879891 | FLG | <  1.0 × 10−3 | <  1.2 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs2689273 | 3:121631451 | cg19216788 | SLC15A2 | 1.0 × 10−3 | 1.8 × 10−3 | 2.0 × 10−3 | 2.8 × 10−3 |
rs9822474 | 3:121637966 | cg07193051 | SLC15A2 | <  1.0 × 10−3 | <  1.2 × 10−3 | 2.0 × 10−3 | 2.8 × 10−3 |
rs351855 | 5:176520243 | cg19956155 | FGFR4 | 2.1 × 10−2 | 2.8 × 10−2 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs3807306 | 7:128580680 | cg26616347 | IRF5 | <  1.0 × 10−3 | <  1.2 × 10−3 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs11227318 | 11:65592935 | cg15531562 | RBM4B | 1.0 × 10−3 | 1.8 × 10−3 | 5.0 × 10−2 | 5.0 × 10−2 |
*rs11227318 | 11:65592935 | cg15531562 | RBM14 | 1.2 × 10−1 | 1.3 × 10−1 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs10791827 | 11:65596546 | cg15531562 | EFEMP2 | <  1.0 × 10−3 | <  1.2 × 10−3 | 1.6 × 10−2 | 1.7 × 10−−2 |
*rs10791827 | 11:65596546 | cg15531562 | PACS1 | 8.3 × 10-1 | 8.3 × 10−1 | 1.0 × 10−−3 | 1.6 × 10−3 |
rs9303281 | 17:38074046 | cg18711369 | ORMDL3 | 1.0 × 10−3 | 1.8 × 10−3 | 1.0 × 10−3 | 1.6 × 10−3 |
*rs2270401 | 17:38176256 | cg10374813 | ERBB2 | 7.2 × 10−1 | 7.8 × 10−−1 | 1.0 × 10−3 | 1.6 × 10−3 |
*rs2302774 | 17:38183090 | cg10374813 | ERBB2 | 7.7 × 10−1 | 8.0 × 10−1 | 5.0 × 10−3 | 5.9 × 10−3 |
rs1029792 | 17:38808941 | cg26165421 | SMARCE1 | 2.1 × 10−2 | 2.8 × 10−2 | <  1.0 × 10−3 | <  2.8 × 10−3 |
rs7223354 | 17:38824672 | cg02645492 | SMARCE1 | 3.6 × 10−2 | 4.3 × 10−2 | 1.0 × 10−3 | 1.6 × 10−3 |
rs132920 | 22:41810170 | cg19274703 | ACO2 | 2.0 × 10−3 | 3.1 × 10−3 | 5.0 × 10−3 | 5.9 × 10−3 |
rs9607819 | 22:41958862 | cg07830128 | PMM1 | 4.0 × 10−3 | 5.9 × 10−3 | 5.0 × 10−3 | 5.9 × 10−3 |
rs5758461 | 22:42162189 | cg10386501 | PMM1 | 3.1 × 10−2 | 3.9 × 10−2 | 2.4 × 10−2 | 2.5 × 10−2 |