Fig. 2

Response to therapy according to Matching Score. A Bar graph analyzing the percentage of patients with progressive disease (PD), stable disease (SD) < 6 months, SD ≥ 6 months, partial response (PR), and complete response (CR) for patients with a Matching Score of ≥ 60% (N = 25) versus < 60% (N = 43). P values were computed using a binary logistic regression test. B Bar graph analyzing the percentage of patients with PD, SD < 6 months, SD ≥ 6 months, PR, and CR for patients with a Matching Score of ≥ 60% (N = 25) versus 1–59% (N = 23) versus unmatched (N = 20). P values were computed as above. Sixty-eight of 76 treated patients were evaluable for response [Matching Score ≥ 60% (N = 25) versus < 60% (N = 43)]. The remaining 8 patients were excluded from this analysis as 5 had ongoing SD for < 6 months and 3 were not yet staged at data cutoff. At the data-cutoff date of November 1, 2019, the overall response rate was 14.5% for all patients. A total of 4 (2.8%) of the patients had a CR, 17 (11.7%) had a PR, 24 (16.6%) had SD (nine with SD ≥ 6 months, ten with SD < 6 months, five with on-going SD for < 6 months), 28 (19.3%) had progressive disease (PD), 3 (19.3%) were too early in treatment for response measurements, and 69 (48%) could not be evaluated, most often owing to early withdrawal for clinical deterioration. All the patients were accounted for in this analysis. CR, complete response; DCR, disease control rate (SD ≥ 6 months with PR/CR); MS, Matching Score; ORR, objective response rate (PR and CR); PD, progressive disease; PR, partial response; SD, stable disease