Table 2 Multivariate analyses of disease control rate, progression-free survival, and overall survival in 76 treatment-naïve patients (N = 76)
DCR (SD ≥ 6mos/PR/CR) (N = 68†) | Progression-free Survival (N = 76) | Overall Survival (N = 76) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameters | Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |||||||||
N | Rate | P value | OR (95% CI) | P value | N | Median (months) | P value | HR (95% CI) | P value | N | Median (months) | P value | HR (95% CI) | P value | |
Age, years | |||||||||||||||
≥63 | 36 | 44% | > 0.99 | -- | -- | 38 | 4.5 | 0.47 | -- | -- | 38 | 15.6 | 0.18 | -- | -- |
< 63 | 32 | 44% | 38 | 4.3 | 38 | NR | |||||||||
Gender | |||||||||||||||
Men | 29 | 48% | 0.63 | -- | -- | 36 | 4.3 | 0.75 | -- | -- | 36 | 17.3 | 0.50 | -- | -- |
Women | 39 | 41% | 40 | 4.3 | 40 | 14.7 | |||||||||
Treatment | |||||||||||||||
Matched | 48 | 54% | 0.02 | 2.57 (0.65-10.21) | 0.18 | 54 | 5.7 | 0.007 | 0.61 (0.31-1.19) | 0.14 | 54 | 17.7 | 0.27 | -- | -- |
Unmatched | 20 | 20% | 22 | 2.1 | 22 | 15.6 | |||||||||
Matching Score | |||||||||||||||
≥ 60% | 25 | 68% | 0.005 | 3.31 (1.01-10.83) | 0.048 | 27 | 11.6 | 0.008 | 0.55 (0.28-1.07) | 0.08 | 27 | 18.7 | 0.053 | 0.42 (0.21-0.85) | 0.02 |
< 60% | 43 | 30% | 49 | 2.8 | 49 | 11.6 | |||||||||
Number of drugs | |||||||||||||||
≥ 2 drugs | 56 | 45% | > 0.99 | -- | -- | 62 | 4.3 | 0.88 | -- | -- | 62 | 14.3 | 0.14 | 2.87 (1.00-8.23) | 0.050 |
Single drug | 12 | 42% | 14 | 5.7 | 14 | 23.0 | |||||||||
GI or HPB cancer‡ | |||||||||||||||
Yes | 34 | 38% | 0.46 | -- | -- | 39 | 3.1 | 0.41 | -- | -- | 39 | 17.3 | 0.74 | -- | -- |
No | 34 | 50% | 37 | 5.7 | 37 | 15.6 | |||||||||
CUP | |||||||||||||||
Yes | 10 | 60% | 0.32 | -- | -- | 10 | 4.3 | 0.74 | -- | -- | 10 | 8.3 | 0.57 | -- | -- |
No | 58 | 41% | 66 | 4.3 | 66 | 15.6 | |||||||||
Breast cancer | |||||||||||||||
Yes | 3 | 67% | 0.58 | -- | -- | 3 | NR | 0.20 | -- | -- | 3 | 14.7 | 0.42 | -- | -- |
No | 65 | 43% | 73 | 4.3 | 73 | 16.0 | |||||||||