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Table 2 Heritability estimates with corresponding 95% confidence intervals for the 13 obesity- and diabetes-related cytokines and hormones in continental Africans with comparison of heritability estimates in other populations

From: Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits

 

Continental Africans

Other populations

 

Trait

Heritability %

SE

95% CI

n

Population

Heritability %

Method

n

Ref

Adipsin

62.8

11.5

40.3–85.3

2761

     

Leptin

32.9

12.5

8.4–57.4

2808

Hispanic

25

Variance component analyses

1030

[56]

GIP

47.6

11.9

24.3–70.9

2810

Swedish

15

GCTA

3344

[24]

GLP-1

21.9

12.2

− 2.0–45.8

2834

Swedish

0

GCTA

3344

[24]

PAI-1

13.3

11.9

− 10.0–36.6

2847

British

20

Variance component analyses

537

[57]

Resistin

24.8

11.0

3.2–46.4

1814

Italian

68

Variance component analyses

264

[58]

     

European American

35

Quantitative trait simulation

2531

[59]

Visfatin

53.6

12.2

29.7–77.5

2803

     

Il-1RAa

--

--

--

1179

     

IL-6a

--

--

--

1125

     

IL-10a

--

--

--

881

     

Insulinb

46.7

11.4

24.4–69.0

2963

     
     

Swedish

10.6

GCTA

3344

[24]

     

Hispanics

19

Variance components decomposition

1030

[56]

Glucagon

70.6

11.7

47.7–93.5

2796

Swedish

20

GCTA

3344

[24]

Ghrelin

58.6

11.1

36.8–80.4

2830

Hispanics

61

Variance components decomposition

1030

[56]

  1. aNo reliable estimate could be derived due to the low sample size for these interleukins
  2. bT2D cases were excluded for all Insulin analyses
  3. SE standard error; CI confidence interval; n, sample size; --, not available; GCTA Genome-Wide Complex Trait Analysis; Ref reference