Table 4 Replication in African Americans and GWAS catalog of genome-wide significant loci per adipocytokine/hormone for the base model
| Â | Â | Â | Â | Replication in AA | Replication in GWAS catalog | |||||
|---|---|---|---|---|---|---|---|---|---|---|
SNP | Chr | Position GRCh37 | Alleles ref/tested | NS | MAF | P value | beta | SE | Heterogeneity P value | PMID: population(s) |
Adipsin | ||||||||||
rs199890456 | 6 | 2914945 | C/T | -- | -- | -- | -- | -- | -- | (novel) |
rs201751833 | 2 | 165079139 | T/G | 1846 | 0.4782 | 0.002 | − 0.113 | 0.037 | -- | (novel) |
 rs1469952 | 2 | 11917519 | G/A | 1846 | 0.4951 | 0.866 | 0.006 | 0.035 | -- | (novel) |
rs115100304 | 2 | 234777140 | C/G | 1846 | 0.0411 | 0.942 | − 0.006 | 0.089 | -- | (novel) |
 rs34061423 | 14 | 91095586 | C/CT,CAT | 1846 | 0.3599 | 0.508 | − 0.024 | 0.037 | -- | (novel) |
rs183172404 | 17 | 20247428 | G/A | 1846 | 0.0389 | 0.554 | − 0.057 | 0.097 | -- | (novel) |
rs539334014 | 11 | 13192725 | G/A,T | -- | -- | -- | -- | -- | -- | (novel) |
 rs79750258 | 2 | 64909796 | T/G | -- | -- | -- | -- | -- | -- | (novel) |
rs111651263 | 7 | 93239919 | T/C | 1846 | 0.0842 | 0.766 | 0.021 | 0.071 | -- | (novel) |
 rs79024755 | 8 | 95715336 | G/T | 1846 | 0.2848 | 0.747 | − 0.016 | 0.048 | -- | (novel) |
rs113529034 | 7 | 146458922 | T/C | 1846 | 0.0245 | 0.169 | − 0.211 | 0.153 | -- | (novel) |
rs180913374 | 2 | 132099516 | C/T | -- | -- | -- | -- | -- | -- | (novel) |
rs145662005 | 17 | 70334651 | G/C | -- | -- | -- | -- | -- | -- | (novel) |
Leptin | ||||||||||
 rs28954105 | 7 | 127891616 | G/T | 1869 | 0.0822 | 0.001 | − 0.214 | 0.063 | -- | 26833098: European ancestry |
rs113453972 | 14 | 64123318 | G/T | 1869 | 0.0398 | 0.476 | − 0.064 | 0.090 | -- | (novel) |
 rs61258383 | 1 | 88355364 | A/G | 1869 | 0.0469 | 0.864 | − 0.014 | 0.082 | -- | (novel) |
 rs9894577 | 17 | 43223292 | G/A | 1869 | 0.2878 | 0.897 | − 0.005 | 0.039 | -- | (novel) |
GIP | ||||||||||
 rs12028926 | 1 | 8818438 | C/G | 1859 | 0.0523 | 0.797 | − 0.021 | 0.081 | -- | (novel) |
 rs62266118 | 3 | 115124821 | A/G | 1859 | 0.0376 | 0.599 | 0.052 | 0.099 | -- | (novel) |
 rs17437121 | 1 | 23640663 | A/G | 1859 | 0.0360 | 0.798 | 0.026 | 0.103 | -- | (novel) |
 rs17335662 | 11 | 11062119 | C/T | 1859 | 0.0495 | 0.567 | 0.048 | 0.085 | -- | (novel) |
rs182578321 | 9 | 85708499 | C/T | -- | -- | -- | -- | -- | -- | (novel) |
rs988623129 | 18 | 44187314 | ATACATATATA CATATATG/A | 1859 | 0.0114 | 0.578 | - 0.101 | 0.182 | -- | (novel) |
GLP-1 | ||||||||||
     rs1355371392 | 2 | 135283403 | C/A | -- | -- | -- | -- | -- | -- | (novel) |
 rs73669122 | 9 | 129313248 | C/T | 1798 | 0.1029 | 0.348 | − 0.058 | 0.062 | -- | (novel) |
     rs1450571579 | 1 | 93402186 | C/A | 1798 | 0.0426 | 0.259 | 0.129 | 0.114 | -- | (novel) |
rs1445210817 | 14 | 64071897 | T/C | -- | -- | -- | -- | -- | -- | (novel) |
rs372701742 | 8 | 25463403 | T/TA | 1798 | 0.0270 | 0.682 | −0.062 | 0.152 | -- | (novel) |
PAI-1 | ||||||||||
 rs113421429 | 7 | 100729247 | C/T | 594 | 0.1641 | 0.103 | 0.151 | 0.093 | 0.869 | 24578379 & 22990020: European ancestry |
 rs61654751 | 19 | 3436093 | TG/T | 594 | 0.1299 | 0.185 | 0.179 | 0.135 | 0.310 | (novel) |
 rs2496687 | 6 | 81340947 | C/G | 594 | 0.7799 | 0.122 | 0.109 | 0.071 | 0.488 | (novel) |
IL1-RA | ||||||||||
 rs202017265 | 18 | 13515503 | A/T | 533 | 0.3761 | 0.308 | − 0.066 | 0.064 | -- | (novel) |
IL-6 | ||||||||||
 rs72911283 | 18 | 8243353 | T/G | 2235 | 0.0208 | 0.094 | 0.112 | 0.401 | 0.166 | (novel) |
Glucagon | ||||||||||
 rs10809430 | 9 | 11345807 | C/G | 1865 | 0.0458 | 0.661 | − 0.036 | 0.082 | -- | (novel) |
Ghrelin | ||||||||||
 3:49318960 | 3 | 49318960 | C/T | -- | -- | -- | -- | -- | -- | (novel) |
 rs150921599 | 2 | 72385239 | C/CA | 1858 | 0.0897 | 0.354 | − 0.058 | 0.062 | -- | (novel) |
 rs183921098 | 6 | 159981730 | G/A | -- | -- | -- | -- | -- | -- | (novel) |
 rs372331930 | 4 | 140418751 | G/GT | 1858 | 0.0340 | 0.809 | − 0.025 | 0.104 | -- | (novel) |
Resistin | ||||||||||
 rs3219175 | 19 | 7733855 | G/A | 1867 | 0.1157 | 9.52E−38 | 0.804 | 0.061 | -- | 24123702, 22843503 & 27664181: Han Chinese, European ancestry, Japanese |