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Fig. 2 | Genome Medicine

Fig. 2

From: Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Fig. 2

Association between 16p11.2 genes and three brain-related traits. Association between predicted expression of 16p11.2 genes and schizophrenia (left), BMI (middle), IQ (right) using MultiXcan (schizophrenia) and S-MultiXcan (BMI, IQ). Genes are listed on the horizontal access in order of chromosomal position. The − log10 p values on the vertical axis are given a positive or negative direction based on the average direction of the single-tissue results. The significance threshold, P < 7.9 × 10−5, is a Bonferroni correction on the total number of 16p11.2 and 22q11.2 genes (127) tested across 5 traits (0.05/(5 × 127)). Genes exceeding the significance threshold in the expected direction (positive for schizophrenia, negative for BMI, either for IQ) are denoted as x’s

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Genome Medicine

ISSN: 1756-994X

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