Fig. 1

Gut microbiome clustering at the ASV level reveals two distinct communities. A Hierarchical clustering of samples based on the JSD distance matrix made using the relative abundance of ASVs reveals two primary clades designated as high risk (GMB1, shown in orange) and low risk (GMB2, shown in blue). B PCoA visualization of the JSD matrix. PERMANOVA analysis results (top of PCoA figure) added to quantify the amount of variance explained by ASV level clustering show a significant association between the GMB1 and GMB2 groups; R² = 0.16, p < 0.001