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Fig. 2 | Genome Medicine

Fig. 2

From: Functional pre-therapeutic evaluation by genome editing of variants of uncertain significance of essential tumor suppressor genes

Fig. 2

Functional characterization of BRCA1/2 variants of unknown significance. A Schematic representation of the introns and exons of the BRCA1 gene, showing the location of the variants selected for this analysis (http://wormw eb.org/exonintron). B Similar representation for the BRCA2 gene. C Functional score evaluation after CRISPR-Cas9 editing and NGS sequencing of BRCA1/2 variants of unknown significance and comparison with the functional scores obtained for functionally normal and abnormal mutations (Mann-Whitney tests, p = 0.0079)

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