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Table 1 Functional scores for the evaluated BRCA1/2 variants and comparison with database annotations

From: Functional pre-therapeutic evaluation by genome editing of variants of uncertain significance of essential tumor suppressor genes

  1. Variants classified as benign in databases (+) or functionally normal in our assay (Normal) are shown in green. Variants classified as pathogenic in databases (-) or functionally abnormal in our assay (Abnormal) are shown in red. Variants with conflicting interpretation are shown in orange (+/-), unreported mutations are shown in yellow (?). Variants with an intermediate score are shown in blue. Functional scores of variants already characterized by Findlay et al. [25] are included where available. Variants which were characterized in our laboratory are marked (X), the others were selected in the databases