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Fig. 4 | Genome Medicine

Fig. 4

From: Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer

Fig. 4

CDC7 inhibitor synergies with AZD6738 or MK-8776 in HCC cells. a, b Short-term colony formation assays showing synergistic response to XL413 (10 μM) combined with AZD6738 or MK-8776 in three HCC cell lines (resistant to ATR or CHK1 inhibitors: Huh6, PLC/PRF/5 and SNU449) after 4–5 days treatment. c Quantification of CellTiter-Blue viability assays of Huh6, PLC/PRF/5, and SNU449 cells treated with XL413, AZD6738, MK-8776 or the combination at the indicated concentrations. d, e Representative images of PLC/PRF/5 and SNU449 cells treated with XL413, AZD6738, MK-8776 or the indicated combinations for 96 h in the presence of a green fluorescent caspase-3/7 activatable dye. The proportion of cells containing caspase-3/7 staining is shown

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Genome Medicine

ISSN: 1756-994X

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