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Fig. 5 | Genome Medicine

Fig. 5

From: Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer

Fig. 5

Combined CDC7 and ATR-CHK1 inhibition leads to defective cell cycle of HCC cells. a, b Representative live cell images of PLC/PRF/5 and SNU449 cells expressing GFP-Histone 2B. Cells treated with XL413 (10 μM), AZD6738 (1.25 μM), MK-8776 (2.5 μM) or the indicated combinations were monitored by time-lapse microscopy. c Quantification of mitosis duration based on time-lapse microscopy analysis (n > 30 cells per cell line and condition). d Percentages of cell fates of PLC/PRF/5 and SNU449 cells in the absence or presence of XL413 (10 μM), AZD6738 (1.25 μM), MK-8776 (2.5 μM) or the indicated combination were analyzed using time-lapse microscopy (n = 50 cells per group). **P < 0.01 and ***P < 0.001

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