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Fig. 2 | Genome Medicine

Fig. 2

From: Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models

Fig. 2

Differential molecular profiling and AD progression. a Number of differentially expressed genes (left panel) and proteins (right panel) comparing the three mouse AD models (AppNL-F, AppNL-G-F, and 3xTg-AD) at different ages with their corresponding, age-matched, wild-type controls. Red and blue represent up- and downregulated genes/proteins, respectively. Bars indicate the number of significant genes/proteins that changed between conditions at different thresholds of false discovery rate (FDR) and with an absolute log fold change (LogFC) larger than 0.5 for mRNA and 0.25 for proteins. Numbers depicted in the figure correspond to FDR < 5%. N = 4 for all the conditions. b Number of differentially expressed genes (left panel) and proteins (right panel) comparing each genotype at the different ages. N = 4 for all the conditions. c Overlap between differentially expressed genes (left panel; absolute LogFC> 0.5, FDR < 5%) or proteins (right panel; absolute LogFC> 0.25, FDR < 5%) comparing AD mouse models and disease stages

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Genome Medicine

ISSN: 1756-994X

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