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Fig. 3 | Genome Medicine

Fig. 3

From: Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models

Fig. 3

Identification and functional annotation of AD signatures. a Heatmap showing the progression of the transcriptional changes in the top-250 genes showing a positive genotype by age interaction (AD-UP signature). Each gene is represented by a row of colored tiles, the color representing the RNA expression level for the indicated condition by column (red, upregulated; blue, downregulated). The bar plot on the right indicates the top-20 significant pathways corresponding to the functional enrichment analysis of these top-250 genes, indicating the adjusted p value on the X-axis. b Normalized gene expression at different time points expressed in months (mo.) for four examples of the AD-UP signature (Cst7, Trem2, Tyrobp, and Cx3cr1) in the AppNL-G-F (red line), AppNL-F (orange line), and Appwt (green line) mice. N = 4. c As in a, progression of the transcriptional changes in the top 250 genes showing a negative genotype by age interaction (AD-DW signature) and functional enrichment analysis of these genes. d As in b, four examples (Gabrb2, Stxbp1, Reln, and Calb1) of the AD-DW signature are shown. N = 4

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