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Fig. 1 | Genome Medicine

Fig. 1

From: A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy

Fig. 1

CanDI integrates multiomics data enabling discovery. A A schematic showing human cell models integrated by CanDI. B A schematic illustrating types of data integrated by CanDI. C A cartoon of a genome-scale CRISPR screen to identify genes that modulate response to PARP inhibition by Olaparib. D A schematic depicting data feature inputs parsed by CanDI. E Essentiality of Fanconi anemia genes in ovarian and breast cancer cell lines separated by BRCA mutation status. Gene essentiality (CERES gene effect score) is displayed by a heat map. N = 6 BRCA1-mutant ovarian cancer, N = 51 BRCA1-wildtype ovarian cancer, N = 4 BRCA1-mutant breast cancer, N = 39 BRCA1-wildtype breast cancer

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