Fig. 3

CanDI reveals female and male context-specific essential genes. A Differential gene expression and differential gene essentiality in male and female CRC cell lines. For differential expression analysis: N = 24 male cell lines and N = 14 female cell lines. For differential essentiality analysis: and N = 18 male cell lines and N = 9 female cell lines. B The distribution of gene effect CERES scores in male and female CRC cell lines. The top seven and bottom three differentially essential genes are shown in violin plots split by the sex of the cell lines. C Differential gene expression and differential gene essentiality in male and female NSCLC cell lines. For differential expression analysis: N = 30 male cell lines and N = 13 female cell lines. For differential essentiality analysis and N = 23 male cell lines and N = 9 female cell lines. D The distribution of gene effect CERES scores in male and female NSCLC cell lines. The top seven and bottom three differentially essential genes are shown in violin plots split by the sex of the cell lines. E Differential gene expression and differential gene essentiality in male and female PDAC cancer cell lines. For differential expression analysis: N = 26 male cell lines and N = 19 female cell lines. For differential essentiality analysis: N = 24 male cell lines and N = 12 female cell lines. F The distribution of gene essentiality CERES scores in male and female PDAC cell lines. The top seven and bottom three differentially essential genes are shown in violin plots split by the sex of the cell lines