Fig. 4

CanDI enables rapid integration of external datasets to reveal immunotherapy targets. A A graph showing genes that are upregulated in KRAS-mutant NSCLC cell lines relative to primary human bronchial epithelial cells. A cell membrane protein localization score is shown for each gene. Higher protein localization scores indicate higher confidence annotations. B A scatter plot showing gene expression for genes that encode cell surface proteins in KRAS-mutant NSCLC cell lines and primary human bronchial epithelial cells. N = 46 for KRAS-mutant NSCLC cell lines and N = 4 for primary human bronchial epithelial cells. C A graph showing genes that are upregulated in EGFR-mutant NSCLC cell lines relative to primary human bronchial epithelial cells. A cell membrane protein localization score is shown for each gene. Higher protein localization scores indicate higher confidence annotations. D A scatter plot showing gene expression for genes that encode cell surface proteins in EGFR-mutant NSCLC cell lines and primary human bronchial epithelial cells. N = 21 for EGFR-mutant NSCLC cell lines and N = 4 for primary human bronchial epithelial cells. E A graph showing genes that are upregulated in NSCLC cell lines relative to primary human bronchial epithelial cells. A cell membrane protein localization score is shown for each gene. Higher protein localization scores indicate higher confidence annotations. F A scatter plot showing gene expression for genes that encode cell surface proteins in NSCLC cell lines and primary human bronchial epithelial cells. N = 141 for NSCLC cell lines and N = 4 for primary human bronchial epithelial cells