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Fig. 5 | Genome Medicine

Fig. 5

From: A mixture model for signature discovery from sparse mutation data

Fig. 5

Performance evaluation on MSK-IMPACT data. A Hyper-parameter selection in Mix. A plot of BIC score (y-axis) as a function of the number of signatures (z-axis) and the number of clusters (x-axis). B De-novo signature discovery from MSK-IMPACT panel data [27, 28]. Shown are sorted cosine similarities between learned signatures and most similar COSMIC [26] signature (denoted next to the plot) for Mix, NMF, and clustered NMF across a range of number of signatures (6-8 corresponding to top, middle and bottom, respectively). Repeating signatures of the same model are in bold. C AMI score as a function of the number of clusters for each model

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