Fig. 4
From: Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer
Intra-tumor heterogeneity and clonal evolution observed in p53mut UCS PDX models. A Somatic genome-wide levels of CNA and B total somatic mutation count in the three UCS models. Tumor purity was estimated by ascatNgs. C Cellular prevalence of the top five mutational clusters with ≥5% of all somatic substitutions detected in the PDX03 model by PyClone. Values shown above boxplots represent the number of substitutions contributing to each cluster. D Fish plots and E cellular population depictions of the top five mutational clusters detected in the PDX03 carcinosarcoma model. Percentages shown in the fish plots are the estimated proportions of cells containing that mutational cluster. F The clonal evolution tree inferred by ClonEvol, where length of branches is proportional to the number of substitutions attributed to that clone. Tumor samples are grouped by patient ID. PDX samples are labeled by passage number (F0—1st transplant, F1—2nd transplant, F2—3rd transplant, etc.) and lineage in brackets (A, B). TNP, triple nucleotide polymorphism