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Table 4 Mycological tests and clinical characteristics of patients with at least one result suggestive of invasive pulmonary Aspergillosis

From: Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units

Patient

A. fumigatus detection in respiratory samples

Galactomannan (positive/tested)

AspICU – Putative Criteria [34]

ECMO

Sample numbera

CMg

qPCR (Cq)

Culture (Positive/Tested)

BAL > 1.0

Serum > 0.5

Radiology

Clinical

Host

563

S28

Positive

31

Positive

  

Yes

Yes

Yes – steroid

No

Other

ND

ND

3/6

0/1

0/0

613

S18

Negative

> 40

Negative

  

Yes

Yes

No

No

Other

ND

ND

2/2

1/1

0/0

677

S63

Negative

> 40

Negative

  

Yes

Yes

Yes – steroid

No

S54

Negative

> 40

Negative

  

S52

Negative

> 40

Negative

  

Other

ND

ND

0/8

2/2

0/5

740

S59

Negative

> 40

Negative

  

Yes

Yes

Yes – leukaemia on chemotherapy

No

S30

Negative

> 40

Negative

  

Other

ND

ND

0/16

1/4

1/2

1033

S8

Positive

33

Positive

  

Yes

Yes

Yes – steroid

Yes

Other

ND

ND

0/0

1/1

1/1

1346

S56

Positive

32

Positive

  

Yes

Yes

Yes – steroid, anakinra

Yes

Other

ND

ND

0/3

1/1

0/2

1440

S33

Negative

> 40

Negative

  

Yes

Yes

Yes – steroid, anakinra

Yes

Other

ND

ND

0/4

1/2

0/1

1457

S65

Negative

> 40

Negative

  

Yes

Yes

Yes – steroid

Yes

S64

Negative

> 40

Negative

  

Other

ND

ND

0/9

2/2

0/2

1538

S55

Positive

31

Negative

  

Yes

Yes

Yes – lymphoma on chemotherapy

No

Other

ND

ND

4/5

0/0

1/1

  1. ND = not done
  2. aOther sample represents samples from the nine patients, retrieved after an ITU episode but were outside the CMg period and were not processed with CMg