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Table 1 GWAS significant (p < 5 × 10-8) SNP associations

From: The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare

SEX CHR BP SNP LOCUS A1 A0 A1 FREQ BETA SE P P (other sex)
CRF-vo2max
 Combined 1 112592672 rs269071 Intergenic1 A G 0.63 0.031 0.005 3.6 × 10-10  
 Combined 2 179747068 rs142556838 CCDC141 C T 0.91 0.049 0.008 2.9 × 10-9  
 Combined 2 179839888 rs10497529 CCDC141 G A 0.96 0.085 0.013 1.0 × 10-11  
 Combined 3 38767315 rs6801957 SCN10A T C 0.41 0.030 0.005 1.7 × 10-10  
 Combined 5 65264090 rs251295 ERBB2IP A G 0.59 −0.027 0.005 2.3 × 10-8  
 Combined 5 121868475 rs111299422 Intergenic2 T TA 0.69 −0.038 0.005 6.5 × 10-14  
 Combined 6 122089704 rs58730006 Intergenic3 A AT 0.90 0.047 0.008 2.7 × 10-9  
 Combined 10 102552663 rs11190709 PAX2 G A 0.11 −0.046 0.007 3.8 × 10-10  
 Combined 16 56803199 rs78291913 NUP93 C T 0.99 −0.143 0.024 1.4 × 10-9  
 Combined 17 43668512 rs527325496 Intergenic4 C CAAA 0.81 −0.036 0.006 4.2 × 10-9  
 Combined 17 44335579 rs139077859 LOC644172 G A 0.79 −0.033 0.006 1.7 × 10-8  
 Combined 20 36849088 rs4811602 KIAA1755 G A 0.53 −0.028 0.005 3.7 × 10-9  
 Malea 3 38773805 rs9809798 SCN10A A C 0.47 0.040 0.007 2.2 × 10-8 6.3 × 10-3
 Maleb 5 121868475 rs111299422 Intergenic2 T TA 0.69 −0.050 0.008 2.6 × 10-10 3.3 × 10-5
 Malec 10 102553647 rs1006545 PAX2 G T 0.11 −0.062 0.011 4.3 × 10-8 2.7 × 10-3
 Maled 14 96864374 rs41317306 AK7 T G 0.98 −0.137 0.024 2.2 × 10-8 5.1 × 10-1
CRF-slope
 Combined 5 121868475 rs111299422 Intergenic2 T TA 0.69 0.007 0.001 1.3 × 10-10  
 Combined 7 100546458 rs4582488 Integenic5 G T 0.74 0.007 0.001 3.6 × 10-9  
 Combined 8 8317817 rs2921060 Intergenic6 A C 0.55 0.006 0.001 1.6 × 10-8  
 Combined 8 10822431 rs35792458 XKR6 G C 0.56 −0.006 0.001 1.5 × 10-8  
 Combined 8 11423072 rs12541800 Intergenic7 A G 0.52 0.006 0.001 4.7 × 10-8  
 Combined 10 102554618 10:102554618_AT_A PAX2 AT A 0.11 0.012 0.002 1.5 × 10-13  
 Combined 12 24758480 rs4963772 Intergenic8 G A 0.85 −0.009 0.001 5.8 × 10-11  
 Combined 12 33633599 rs7303356 Intergenic9 G C 0.49 −0.006 0.001 1.5 × 10-10  
 Femalee 5 121868475 rs111299422 Intergenic2 T TA 0.69 0.010 0.002 2.5 × 10-8 1.1 × 10-3
 Malef 10 102553647 rs1006545 PAX2 G T 0.11 0.012 0.002 6.0 × 10-12 2.0 × 10-5
 Maleg 20 4131944 rs1741294 SMOX C G 0.96 0.016 0.003 6.0 × 10-9 6.0 × 10-1
PA
 Combined 1 78450517 rs34517439 Intergenic10 C A 0.88 0.316 0.058 4.6 × 10-8  
 Combined 5 87942506 rs10067451 LINC00461 G A 0.89 0.333 0.060 3.0 × 10-8  
 Combined 5 152238114 5:152238114* LOC101927134 TTTTTTTTTTTTC T 0.71 0.230 0.042 4.1 × 10-8  
 Combined 9 128195657 rs1268539 Intergenic11 C A 0.58 −0.214 0.038 1.9 × 10-8  
 Combined 10 21885577 rs34719019 MLLT10 A T 0.73 0.242 0.042 9.7 × 10-9  
 Combined 17 43758125 rs62055696 CRHR1 A G 0.78 −0.309 0.046 1.3 × 10-11  
 Combined 17 44326864 rs2696625 Intergenic12 A G 0.77 −0.310 0.045 4.8 × 10-12  
 Combined 17 44828931 rs199533 NSF G A 0.79 −0.250 0.046 4.0 × 10-8  
 Combined 18 40768309 rs59499656 Intergenic13 A T 0.66 −0.215 0.039 5.0 × 10-8  
 Femaleh 16 71464058 rs75986475 Intergenic14 C G 0.88 −0.436 0.076 7.4 × 10-9 3.3 × 10-1
 Femalei 16 80784797 rs13329850 CDYL2 C G 0.74 −0.308 0.055 2.8 × 10-8 4.5 × 10-1
 Femalej 17 43758125 rs62055696 CRHR1 A G 0.78 −0.358 0.059 1.3 × 10-9 2.4 × 10-4
 Femalek 17 44262581 17:44262581_A_C KANSL1 A C 0.83 −0.450 0.070 1.5 × 10-10 8.2 × 10-3
 Malel 2 36592600 rs78661713 CRIM1 G A 0.94 −0.700 0.128 4.8 × 10-8 6.1 × 10-1
  1. Note: These are independent SNP associations determined by p value informed LD clumping (SNPs correlated 0.2 or greater in a 500 kb). 2 CRF-slope-associated SNPs (rs587631263, chr7; rs10623635, chr10) and 16 PA-associated SNPs (rs10828247, chr10; 15 chr17 SNPs listed in supplementary material) not available in LD reference data. LOCUS nearest gene, A1 effect allele, A0 reference allele, A1 FREQ effect allele frequency, BETA effect size (from BOLT-LMM approximation to infinitesimal mixed model), SE standard error of the effect size
  2. *5:152238114_TTTTTTTTTTTTC_T
  3. 1LOC643355 (+51.2kb), CTTNBP2NL (−346.1kb); 2MGC32805 (+53.7kb), LOC101927379 (−96.2kb); 3GJA1 (+318.8kb), HSF2 (−631kb); 4LOC644172 (−9.0kb), LRRC37A4P (+70.62kb); 5MUC3A (−0.593kb), ACHE (+52.87kb); 6SGK223 (+78.47kb), CLDN23 (−241.8kb); 7BLK (+0.964kb), LINC00208 (−10.97kb); 8LINC00477 (+21.38kb), BCAT1 (−204.5kb); 9SYT10 (+40.84kb), ALG10 (−541.6kb); 10FUBP1 (+5.74kb), DNAJB4 (−20.12kb); 11MAPKAP1 (−4.015kb), GAPVD1 (+68.37kb); 12LOC644172 (+3.71kb), LRRC37A (−45.63kb); 13RIT2 (+72.65kb), SYT4 (−79.55kb); 14ZNF23 (−17.44kb), CALB2 (+39.72kb)
  4. aFemale BETA = 0.0163, SE = 0.0060: Q = 6.58, p = 1.0 × 10-2; I2 = 84.8%, 95% CI = 38.0% – 96.3% (nsCRF = not significant at 0.05/7, for 7 CRF SNPs tested)
  5. bFemale BETA = −0.0271, SE = 0.0065: Q = 4.86, p = 2.8 × 10-2; I2 = 79.4%, 95% CI = 11.1–95.2% (nsCRF)
  6. cFemale BETA = −0.0281, SE = 0.0094: Q = 5.34, p = 2.1 × 10-2; I2 = 81.3%, 95% CI = 20.3–95.6% (nsCRF)
  7. dFemale BETA = 0.0136, SE = 0.0206: Q = 22.13, p < 0.001; I2 = 95.5%, 95% CI = 86.8–98.5%
  8. emale BETA = 0.0038, SE = 0.0012: Q = 8.37, p = 3.8 × 10-3; I2 = 88.1%, 95% CI = 54.1–96.9%
  9. fFemale BETA = 0.0111, SE = 0.0026: Q = 0.04, p = 8.3 × 10-1; I2 = 0.0% (nsCRF)
  10. gFemale BETA = 0.0021, SE = 0.0040: Q = 7.96, p = 4.8 × 10-3; I2 = 87.4%, 95% CI = 51.1–96.8%
  11. hMale BETA = −0.0893, SE = 0.0916: Q = 8.51, p = 3.5 × 10-3; I2 = 88.3%, 95% CI = 55.0–96.9%
  12. iMale BETA = 0.0503, SE = 0.0670: Q = 16.98, p < 0.001; I2 = 94.1%, 95% CI = 81.4–98.1%
  13. jMale BETA = -0.2636, SE = 0.0718: Q = 1.03, p = 3.1 × 10-1; I2 = 3.0% (nsPA = not significant at 0.05/5, for 5 PA SNPs tested)
  14. kMale BETA = −0.2258, SE = 0.0855: Q = 4.09, p = 4.3 × 10-2; I2 = 75.6%, 95% CI = 0.0–94.5% (nsPA)
  15. lFemale BETA = 0.0542, SE = 0.1057: Q = 20.63, p < 0.001; I2 = 95.2%, 95% CI = 85.5–98.4%