SEX

CHR

BP

SNP

LOCUS

A1

A0

A1 FREQ

BETA

SE

P

P (other sex)


CRFvo2max

Combined

1

112592672

rs269071

Intergenic^{1}

A

G

0.63

0.031

0.005

3.6 × 10^{10}
 
Combined

2

179747068

rs142556838

CCDC141

C

T

0.91

0.049

0.008

2.9 × 10^{9}
 
Combined

2

179839888

rs10497529

CCDC141

G

A

0.96

0.085

0.013

1.0 × 10^{11}
 
Combined

3

38767315

rs6801957

SCN10A

T

C

0.41

0.030

0.005

1.7 × 10^{10}
 
Combined

5

65264090

rs251295

ERBB2IP

A

G

0.59

−0.027

0.005

2.3 × 10^{8}
 
Combined

5

121868475

rs111299422

Intergenic^{2}

T

TA

0.69

−0.038

0.005

6.5 × 10^{14}
 
Combined

6

122089704

rs58730006

Intergenic^{3}

A

AT

0.90

0.047

0.008

2.7 × 10^{9}
 
Combined

10

102552663

rs11190709

PAX2

G

A

0.11

−0.046

0.007

3.8 × 10^{10}
 
Combined

16

56803199

rs78291913

NUP93

C

T

0.99

−0.143

0.024

1.4 × 10^{9}
 
Combined

17

43668512

rs527325496

Intergenic^{4}

C

CAAA

0.81

−0.036

0.006

4.2 × 10^{9}
 
Combined

17

44335579

rs139077859

LOC644172

G

A

0.79

−0.033

0.006

1.7 × 10^{8}
 
Combined

20

36849088

rs4811602

KIAA1755

G

A

0.53

−0.028

0.005

3.7 × 10^{9}
 
Male^{a}

3

38773805

rs9809798

SCN10A

A

C

0.47

0.040

0.007

2.2 × 10^{8}

6.3 × 10^{3}

Male^{b}

5

121868475

rs111299422

Intergenic^{2}

T

TA

0.69

−0.050

0.008

2.6 × 10^{10}

3.3 × 10^{5}

Male^{c}

10

102553647

rs1006545

PAX2

G

T

0.11

−0.062

0.011

4.3 × 10^{8}

2.7 × 10^{3}

Male^{d}

14

96864374

rs41317306

AK7

T

G

0.98

−0.137

0.024

2.2 × 10^{8}

5.1 × 10^{1}

CRFslope

Combined

5

121868475

rs111299422

Intergenic^{2}

T

TA

0.69

0.007

0.001

1.3 × 10^{10}
 
Combined

7

100546458

rs4582488

Integenic^{5}

G

T

0.74

0.007

0.001

3.6 × 10^{9}
 
Combined

8

8317817

rs2921060

Intergenic^{6}

A

C

0.55

0.006

0.001

1.6 × 10^{8}
 
Combined

8

10822431

rs35792458

XKR6

G

C

0.56

−0.006

0.001

1.5 × 10^{8}
 
Combined

8

11423072

rs12541800

Intergenic^{7}

A

G

0.52

0.006

0.001

4.7 × 10^{8}
 
Combined

10

102554618

10:102554618_AT_A

PAX2

AT

A

0.11

0.012

0.002

1.5 × 10^{13}
 
Combined

12

24758480

rs4963772

Intergenic^{8}

G

A

0.85

−0.009

0.001

5.8 × 10^{11}
 
Combined

12

33633599

rs7303356

Intergenic^{9}

G

C

0.49

−0.006

0.001

1.5 × 10^{10}
 
Female^{e}

5

121868475

rs111299422

Intergenic^{2}

T

TA

0.69

0.010

0.002

2.5 × 10^{8}

1.1 × 10^{3}

Male^{f}

10

102553647

rs1006545

PAX2

G

T

0.11

0.012

0.002

6.0 × 10^{12}

2.0 × 10^{5}

Male^{g}

20

4131944

rs1741294

SMOX

C

G

0.96

0.016

0.003

6.0 × 10^{9}

6.0 × 10^{1}

PA

Combined

1

78450517

rs34517439

Intergenic^{10}

C

A

0.88

0.316

0.058

4.6 × 10^{8}
 
Combined

5

87942506

rs10067451

LINC00461

G

A

0.89

0.333

0.060

3.0 × 10^{8}
 
Combined

5

152238114

5:152238114*

LOC101927134

TTTTTTTTTTTTC

T

0.71

0.230

0.042

4.1 × 10^{8}
 
Combined

9

128195657

rs1268539

Intergenic^{11}

C

A

0.58

−0.214

0.038

1.9 × 10^{8}
 
Combined

10

21885577

rs34719019

MLLT10

A

T

0.73

0.242

0.042

9.7 × 10^{9}
 
Combined

17

43758125

rs62055696

CRHR1

A

G

0.78

−0.309

0.046

1.3 × 10^{11}
 
Combined

17

44326864

rs2696625

Intergenic^{12}

A

G

0.77

−0.310

0.045

4.8 × 10^{12}
 
Combined

17

44828931

rs199533

NSF

G

A

0.79

−0.250

0.046

4.0 × 10^{8}
 
Combined

18

40768309

rs59499656

Intergenic^{13}

A

T

0.66

−0.215

0.039

5.0 × 10^{8}
 
Female^{h}

16

71464058

rs75986475

Intergenic^{14}

C

G

0.88

−0.436

0.076

7.4 × 10^{9}

3.3 × 10^{1}

Female^{i}

16

80784797

rs13329850

CDYL2

C

G

0.74

−0.308

0.055

2.8 × 10^{8}

4.5 × 10^{1}

Female^{j}

17

43758125

rs62055696

CRHR1

A

G

0.78

−0.358

0.059

1.3 × 10^{9}

2.4 × 10^{4}

Female^{k}

17

44262581

17:44262581_A_C

KANSL1

A

C

0.83

−0.450

0.070

1.5 × 10^{10}

8.2 × 10^{3}

Male^{l}

2

36592600

rs78661713

CRIM1

G

A

0.94

−0.700

0.128

4.8 × 10^{8}

6.1 × 10^{1}

 Note: These are independent SNP associations determined by p value informed LD clumping (SNPs correlated 0.2 or greater in a 500 kb). 2 CRFslopeassociated SNPs (rs587631263, chr7; rs10623635, chr10) and 16 PAassociated SNPs (rs10828247, chr10; 15 chr17 SNPs listed in supplementary material) not available in LD reference data. LOCUS nearest gene, A1 effect allele, A0 reference allele, A1 FREQ effect allele frequency, BETA effect size (from BOLTLMM approximation to infinitesimal mixed model), SE standard error of the effect size
 *5:152238114_TTTTTTTTTTTTC_T
 ^{1}LOC643355 (+51.2kb), CTTNBP2NL (−346.1kb); ^{2}MGC32805 (+53.7kb), LOC101927379 (−96.2kb); ^{3}GJA1 (+318.8kb), HSF2 (−631kb); ^{4}LOC644172 (−9.0kb), LRRC37A4P (+70.62kb); ^{5}MUC3A (−0.593kb), ACHE (+52.87kb); ^{6}SGK223 (+78.47kb), CLDN23 (−241.8kb); ^{7}BLK (+0.964kb), LINC00208 (−10.97kb); ^{8}LINC00477 (+21.38kb), BCAT1 (−204.5kb); ^{9}SYT10 (+40.84kb), ALG10 (−541.6kb); ^{10}FUBP1 (+5.74kb), DNAJB4 (−20.12kb); ^{11}MAPKAP1 (−4.015kb), GAPVD1 (+68.37kb); ^{12}LOC644172 (+3.71kb), LRRC37A (−45.63kb); ^{13}RIT2 (+72.65kb), SYT4 (−79.55kb); ^{14}ZNF23 (−17.44kb), CALB2 (+39.72kb)
 ^{a}Female BETA = 0.0163, SE = 0.0060: Q = 6.58, p = 1.0 × 10^{2}; I^{2} = 84.8%, 95% CI = 38.0% – 96.3% (ns_{CRF} = not significant at 0.05/7, for 7 CRF SNPs tested)
 ^{b}Female BETA = −0.0271, SE = 0.0065: Q = 4.86, p = 2.8 × 10^{2}; I^{2} = 79.4%, 95% CI = 11.1–95.2% (ns_{CRF})
 ^{c}Female BETA = −0.0281, SE = 0.0094: Q = 5.34, p = 2.1 × 10^{2}; I^{2} = 81.3%, 95% CI = 20.3–95.6% (ns_{CRF})
 ^{d}Female BETA = 0.0136, SE = 0.0206: Q = 22.13, p < 0.001; I^{2} = 95.5%, 95% CI = 86.8–98.5%
 ^{e}male BETA = 0.0038, SE = 0.0012: Q = 8.37, p = 3.8 × 10^{3}; I^{2} = 88.1%, 95% CI = 54.1–96.9%
 ^{f}Female BETA = 0.0111, SE = 0.0026: Q = 0.04, p = 8.3 × 10^{1}; I^{2} = 0.0% (ns_{CRF})
 ^{g}Female BETA = 0.0021, SE = 0.0040: Q = 7.96, p = 4.8 × 10^{3}; I^{2} = 87.4%, 95% CI = 51.1–96.8%
 ^{h}Male BETA = −0.0893, SE = 0.0916: Q = 8.51, p = 3.5 × 10^{3}; I^{2} = 88.3%, 95% CI = 55.0–96.9%
 ^{i}Male BETA = 0.0503, SE = 0.0670: Q = 16.98, p < 0.001; I^{2} = 94.1%, 95% CI = 81.4–98.1%
 ^{j}Male BETA = 0.2636, SE = 0.0718: Q = 1.03, p = 3.1 × 10^{1}; I^{2} = 3.0% (ns_{PA} = not significant at 0.05/5, for 5 PA SNPs tested)
 ^{k}Male BETA = −0.2258, SE = 0.0855: Q = 4.09, p = 4.3 × 10^{2}; I^{2} = 75.6%, 95% CI = 0.0–94.5% (ns_{PA})
 ^{l}Female BETA = 0.0542, SE = 0.1057: Q = 20.63, p < 0.001; I^{2} = 95.2%, 95% CI = 85.5–98.4%