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Fig. 4 | Genome Medicine

Fig. 4

From: Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intra-tumoral immune signature benefit from pembrolizumab: results from a single-arm phase 2 trial

Fig. 4

Single-cell characterization of immune cells via scRNA-seq. A t-stochastic neighbor embedding (tSNE) analysis of 26,541 immune cells from 10 patients before and after 2 cycles of pembrolizumab treatment. Cell type clusters were identified and annotated using scCATCH and are denoted by distinct color based on respective cell types. B tSNE analysis of immune cells colored by representative cell type markers, including S100AB, KLRF1, CD8A, and TCL1A. C Dot plot analysis of each cell type cluster and their representative markers. Colors indicate average expression levels, while the size of each dot represents the percentage of cells expressing the respective marker. D tSNE analysis of immune cells colored by patient identity. E Bar graph representation of immune cell composition based on individual patient. Each immune cell type has been normalized based on individual patient

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