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Fig. 1 | Genome Medicine

Fig. 1

From: Germline HLA-B evolutionary divergence influences the efficacy of immune checkpoint blockade therapy in gastrointestinal cancer

Fig. 1

Landscape of classic HLA class I evolutionary divergence in advanced GI cancer. a Schematic diagram of the PUCH study design. The HLA genotype and HED were obtained from 84 patients, and FFPE samples from 76 patients were subjected to WES analysis and RNA profiling. b Distributions of HED at HLA-A, HLA-B, HLA-C, and mean HED across different GI cancer types in the PUCH cohort. c Comparison of HED distributions among HLA-A, HLA-B, and HLA-C heterozygous genotypes. ****p < 0.0001. Kruskal-Wallis test

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Genome Medicine

ISSN: 1756-994X

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