Fig. 2

Associations between HED and immunotherapeutic efficacy and the prognosis. a–c Kaplan-Meier survival analysis comparing OS between patients with high and low HED at each locus: HLA-A (a), HLA-B (b), and HLA-C (c). Patients were dichotomized into low-HED and high-HED subgroups with differential risks for OS by using the optimal cutoff values determined by the “surv_cutpoint” function of the “survminer” R package. d–f Kaplan-Meier survival analysis comparing PFS between patients with high and low HED at each locus: HLA-A (d), HLA-B (e), and HLA-C (f) (PFS information was available for 83 patients). g Forest plot showing the HRs and 95% CIs for the associations of potential prognostic factors (HLA-B HED, TMB, and MSI) with OS in multivariable Cox proportional hazards model (all information was available for 76 patients). h Forest plot showing the ORs and 95% CIs for the associations of germline determinants with DCB