Fig. 4

Joint utility of HLA-B HED and TMB in predicting immunotherapeutic outcomes of GI cancer patients. a Proportions of patients with DCB calculated within each of the three indicated subgroups. b Waterfall plot of tumor response to ICB according to the joint biomarker (HLA-B HED and TMB). The Y-axis represents the percentage of maximum tumor change from baseline according to RECIST 1.1. c Kaplan-Meier survival analysis of PFS among patients within each of the three indicated subgroups in the PUCH cohort (n = 75, the PFS information was not available for one patient). d Kaplan-Meier survival analysis of OS among patients within each of the three indicated subgroups in the PUCH cohort (n = 76). e Kaplan-Meier survival analysis of OS among patients within each of the three indicated subgroups in the MSK GI cohort (n = 84, the MSK GI cohort included 84 patients in all). For both cohorts: Both high, HLA-B HED > 8.61 and TMB > 5.22 mut/Mb; single high, HLA-B HED > 8.61 or TMB > 5.22 mut/Mb; and both low, HLA-B HED ≤ 8.61 and TMB ≤ 5.22 mut/Mb