Fig. 1

ClinGen FDA-recognized variant curation process and VCI. Overview of the ClinGen variant curation process using the VCI, an FDA-recognized workflow. Biocurators select a variant and evaluate evidence that falls into six categories. VCI viewers may view all evidence available for any variant using the VCI. The VCI supports users in making a final pathogenicity classification keeping with the ACMG/AMP guidelines. ClinGen expert panels then disseminate their variant classifications through two community resources: the Evidence Repository (ERepo) and ClinVar