Fig. 4

Significant microbial and functional associations of disease diagnostics and medication intake. a A heatmap depicting the top 50 associations across 27 disease diagnostics and medications colored by the -log(q value)*sign(coefficient). Significant associations (corrected p<0.05) are indicated by an asterisk. b Network of significant associations between microbial taxa (purple circles) and CVD risk, diabetes, metabolic syndrome, antihypertensives, LDL-lowering drugs, and insulin and hypoglycemic drugs (orange circles). The thickness of edge (gray) is defined by the strength of Spearman correlation (r) between the relative abundance of the OTUs and each feature; heavier edge weight implies stronger correlation. c Bar plot of the log fold change of the average relative abundance for significant OTUs associated with CVD status. d A heatmap depicting the top 15 functional pathway associations predicted from PICRUSt across 8 cardiometabolic diagnostics and medications colored by the -log(q value)*sign(coefficient). Significant associations (corrected p<0.05) are indicated by an asterisk