Fig. 4

Associations between L-scores and genomic features. A–C The correlation between L-score and non-silent mutation rate (A), aneuploidy score (B), and homologous recombination defects (C), respectively. D Genes with mutation status significantly correlated with the L-score of samples. E Genes with amplification/deletion status significantly correlated with the L-score of samples. F TP53 mutant samples show significantly lower L-scores than wild-type samples. G No significant correlation between EGFR mutation status and L-scores. H EGFR amplified samples show significantly lower L-scores than wild-type samples. In D–H, p-values were calculated by using the Wilcoxon rank sum test. SCC Spearman correlation coefficient