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Table 5 Results from Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Upregulated and downregulated host genes identified from the comparison between high vs. low Shewanella count group were used for KEGG pathway analysis

From: Microbiota of the prostate tumor environment investigated by whole-transcriptome profiling

Significant KEGG pathways in upregulated genes

Pathway

Fold enrichment

p value

p adj

Oxidative phosphorylation

21.88

1.32e−11

4.74e−10

Parkinson’s disease

20.49

2.56e−11

4.74e−10

Metabolic pathways

3.25

1.77e−05

2.19e−04

Cardiac muscle contraction

17.63

1.38e−04

0.0012

Alzheimer’s disease

7.87

0.0029

0.0215

Huntington’s disease

6.89

0.0046

0.0289

Significant KEGG pathways in downregulated genes

Pathway

Fold enrichment

p value

p adj

Toll-like receptor signaling pathway

12.61

1.31e−05

8.91e−04

  1. p-adj p value corrected for false discovery rate