Fig. 5

Comparison of multiple CRISPR screens identifying host factors promoting SARS-CoV-2 infection of human cell lines. A Data from four recently published CRISPR screens for SARS-CoV-2 in various human cell lines were reanalyzed and compared to our data to identify common top-scoring genes (FDR < 0.25). Using this criterion, there were 74 genes identified in our study, 53 in Daniloski et al., 707 in Schneider et al., 13 in Wang et al., and 1 in Baggen et al. No common genes were identified in all studies, 1 gene was identified in four studies, 6 genes were identified in three studies, and 25 genes were identified in two studies. Fifty-three genes were uniquely identified in our study as significant. B The heat map displays the log₂FC for the 32 genes found in common across two or more of the published studies with FDR < 0.25. C A heat map displaying the log₂FC for the 53 genes uniquely identified as significant in our studies compared to their observed log₂FC across the other published studies