Table 1 Significant associations between tumor somatic mutation counts and germline PRS
From: Somatic mutational profiles and germline polygenic risk scores in human cancer
Cancer type | Somatic mutation count | Germline PRSa | Direction of associationb | p valuec |
|---|---|---|---|---|
PRAD | SBS1 | Age at menarche | − | 2.49 × 10−9 |
PRAD | SBS1 | IBD | + | 9.04 × 10−6 |
PRAD | SBS1 | CD | + | 4.63 × 10−8 |
PRAD | SBS1 | UC | + | 3.71 × 10−9 |
PRAD | SBS1 | GBM | − | 3.29 × 10−8 |
PRAD | SBS1 | HNSC | − | 2.07 × 10−9 |
PRAD | SBS1 | BMI | + | 6.09 × 10−8 |
PRAD | SBS1 | Drinks per week | − | 1.69 × 10−5 |
BRCA | APOBEC-relatedd | IBD | + | 1.79 × 10−6 |
BRCA | SBS1 | Age at menarche | + | 1.47 × 10−5 |
BRCA ER+ | SBS1 | Age at menarche | + | 2.89 × 10−5 |
BRCA ER- | SBS1 | HNSC | − | 1.99 × 10−6 |
BRCA ER- | TSMC | HNSC | − | 5.31 × 10−7 |
COAD | SBS1 | Cigarettes per day | − | 1.71 × 10−5 |
COAD | TSMC | HNSC | − | 1.71 × 10−5 |
GBM | SBS1 | OV | + | 1.97 × 10−5 |
UCEC | SBS40 | CD | − | 7.71 × 10−7 |