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Fig. 3 | Genome Medicine

Fig. 3

From: Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19

Fig. 3

Integrative analysis identifies genetic associations between peripheral immune cells and severe COVID-19. A Bar graph showing the results of the combination of scRNA-seq data and GWAS summary statistics on severe COVID-19 based on the RolyPoly among normal controls and patients with different severities (i.e., mild, moderate, and severe). The y-axis shows the 13 cell types, and the x-axis shows the mean negative log-transformation P value (-Log2(P)). Orange color indicates a cell type showing a significant association, and light blue represents there is no significant association. B UMAP projections of peripheral immune cells colored by annotated cell types. The plot showing the region of CD16+monocytes, megakaryocytes, and memory CD8+T cells. The red dot represents positive gene expressions of CCR1+, ABO+, and CXCR6+, and gray stands for negative cells

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Genome Medicine

ISSN: 1756-994X

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