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Fig. 6 | Genome Medicine

Fig. 6

From: Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19

Fig. 6

Cell-to-cell interactions of CCR1+ CD16+momocytes and CXCR6+ memory CD8+T cells with other cells in PBMC and BALF. A, B Boxplot showing the number of cellular interactions of ACCR1+ CD16+ monocytes and BCCR1− CD16+ monocytes with other immune cells in PBMC between normal controls and patients with increased COVID-19 severities. C Predicted cellular interactions of CCR1+ CD16+ monocytes with other immune cells in PBMC, comparing severe COVID-19 vs. normal control. D, E Boxplot showing the number of cellular interactions of DCXCR6+ memory CD8+T cells and ECXCR6− memory CD8+T cells with other immune cells in PBMC between normal controls and patients with increased COVID-19 severities. F Predicted cellular interactions of CXCR6+ memory CD8+T cells with other immune cells in PBMC, comparing severe COVID-19 vs. normal control. G Boxplot showing an increase in cellular interactions with other cells in BALF for CCR1+ CD16+ monocytes than CCR1− CD16+ monocytes. H Predicted cellular interactions with other cells in BALF, comparing CCR1+ CD16+ monocytes with CCR1− CD16+ monocytes. I Boxplot showing an increase in cellular interactions with other cells in BALF for CXCR6+ memory CD8+T cells than CXCR6− memory CD8+T cells. J Predicted cellular interactions with other cells in BALF, comparing CXCR6+ memory CD8+T cells with CXCR6− memory CD8+T cells. The circular size represents the significance of each ligand-receptor axis, and color represents the communication probability

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