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Fig 3. | Genome Medicine

Fig 3.

From: PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease

Fig 3.

Plcg2 expression is increased exclusively in microglia in the brains of 5xFAD mice. Plcg2 levels were assessed in cortical and hippocampal lysates from 5xFAD mice. There were significant changes in Plcg2 gene expression in both the a cortex and b hippocampus at 4, 6, and 8 months of age (n=4–8 mice). However, increased Plcg2 expression levels were abolished after the PLX5622 treatment (c) and restored after switching the PLX diet to a normal diet (d) (n=3–10). **p<0.01; ***p<0.001; ****p<0.0001, ns not significant

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