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Table 1 Characterization of the 28 identified host gene expression signatures

From: Systematic comparison of published host gene expression signatures for bacterial/viral discrimination

Signature code

Publication first author

Publication last author

Number of genes

Discovery age group

Discovery phenotypes

TS1 [7]

Tang

Schughart

1

Adults

Viral (influenza), healthy

HL2a [8]

Herberg

Levin

2

Pediatrics

Bacterial, viral

LC2 [9]

Lei

Chen

2

All

Bacterial, viral, healthy, SIRS

XW2 [10]

Xu

Wang

2

All

Bacterial, viral, healthy, SIRS

GS3 [11]

Gomez-Carballo

Salas

3

All

Bacterial, viral

LS3 [12]

Li

Sriskandan

3

Adults

Viral (w/ COVID), bacterial, SIRS

SB4a [13]

Sampson

Brandon

4

All

Viral, SIRS

SK7a [14]

Sweeney

Khatri

7

All

Bacterial, viral, SIRS

SB8 [13]

Sampson

Brandon

8

All

Viral, SIRS

RC10 [15]

Ravichandran

Chandra

10

All

Bacterial, viral, healthy

SN10 [16]

Sampson

Noursadeghi

10

All

Bacterial, viral, healthy, SIRS

SR10 [17]

Suarez

Ramilo

10

Adults

Bacterial, viral, co-infection, healthy

AK11 [18]

Andres-Terre

Khatri

11

All

Bacterial, viral, healthy, SIRS

BF11 [19]

Bhattacharya

Falsey

11

Adults

Bacterial, viral

NC19 [20]

Ng

Chiu

19

Adults

Viral (w/ COVID), bacterial, healthy

SL20 [21]

Song

Lei

20

All

Bacterial, viral, healthy, SIRS

MW23 [22]

McClain

Woods

23

All

Viral (w/ COVID), bacterial, healthy

ZG25a [23]

Zaas

Ginsburg

25

Adults

Viral, healthy

MS29 [24]

Mayhew

Sweeney

29

All

Bacterial, viral, healthy, SIRS

PT29 [25]

Parnell

Tang

29

Adults

Bacterial, viral, healthy, SIRS

RC31 [26]

Ramilo

Chaussabel

31

Pediatrics

Bacterial, viral

HS33 [27]

Hu

Storch

33

Infants

Bacterial, viral, healthy

HL34 [8]

Herberg

Levin

34

Pediatrics

Bacterial, viral

ZG48 [28]

Zaas

Ginsburg

48

Adults

Viral, healthy

MR59 [29]

Mahajan

Ramilo

59

Neonates

Bacterial, viral, healthy

TW96 [30]

Tsalik

Woods

96

Adults

Bacterial, viral, SIRS

MW139 [22]

McClain

Woods

139

All

Viral (w/COVID), Bacterial, healthy

AK398 [18]

Andres-Terre

Khatri

398

All

Bacterial, viral, healthy, SIRS

All

-

-

864

-

-

  1. Published host gene expression signatures varied in size and discovery cohort characteristics. Signatures were named using the first and last author’s initials, followed by the number of unique genes in the signature. Neonates include subjects <3 months of age; infants include subjects <3 years of age; Pediatrics includes subjects <18 years of age. aSignature is a subset of another published signature