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Table 3 Overall signature classification performance stratified by dataset characteristics

From: Systematic comparison of published host gene expression signatures for bacterial/viral discrimination

Parameter

Bacterial vs. non-bacterial

Viral vs. non-viral

Median AUC

IQR

p-value

N

Median AUC

IQR

p-value

N

All datasets

0.832

[0.796–0.849]

-

31

0.884

[0.864–0.896]

-

37

Age

-

-

-

-

-

-

-

-

Adult only

0.846

[0.826–0.870]

-

14

0.916

[0.906–0.935]

-

12

Pediatric only

0.798

[0.756–0.818]

< 0.001

15

0.860

[0.841–0.870]

< 0.001

24

# of phenotypes

-

-

-

-

-

-

-

-

2 phenotypes

0.871

[0.846–0.894]

-

12

0.911

[0.880–0.923]

-

22

>2 phenotypes

0.819

[0.788–0.835]

< 0.001

19

0.855

[0.838–0.874]

< 0.001

15

Biological source

-

-

-

-

-

-

-

-

Whole blood

0.838

[0.802–0.859]

-

28

0.884

[0.865–0.900]

-

32

PBMC

0.705

[0.668–0.753]

< 0.001

3

0.831

[0.791–0.882]

0.012

4

  1. AUCs were calculated for each of the 29 evaluated signatures and then stratified by different dataset characteristics. Mean AUCs were first generated for each signature across the datasets in the parameter group, weighted by the number of subjects in each validation dataset. The median of the weighted AUC values and IQR were then calculated and presented here. N represents the number of datasets for the specified cohort composition.
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Genome Medicine

ISSN: 1756-994X

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