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Table 3 Overall signature classification performance stratified by dataset characteristics

From: Systematic comparison of published host gene expression signatures for bacterial/viral discrimination

Parameter Bacterial vs. non-bacterial Viral vs. non-viral
Median AUC IQR p-value N Median AUC IQR p-value N
All datasets 0.832 [0.796–0.849] - 31 0.884 [0.864–0.896] - 37
Age - - - - - - - -
Adult only 0.846 [0.826–0.870] - 14 0.916 [0.906–0.935] - 12
Pediatric only 0.798 [0.756–0.818] < 0.001 15 0.860 [0.841–0.870] < 0.001 24
# of phenotypes - - - - - - - -
2 phenotypes 0.871 [0.846–0.894] - 12 0.911 [0.880–0.923] - 22
>2 phenotypes 0.819 [0.788–0.835] < 0.001 19 0.855 [0.838–0.874] < 0.001 15
Biological source - - - - - - - -
Whole blood 0.838 [0.802–0.859] - 28 0.884 [0.865–0.900] - 32
PBMC 0.705 [0.668–0.753] < 0.001 3 0.831 [0.791–0.882] 0.012 4
  1. AUCs were calculated for each of the 29 evaluated signatures and then stratified by different dataset characteristics. Mean AUCs were first generated for each signature across the datasets in the parameter group, weighted by the number of subjects in each validation dataset. The median of the weighted AUC values and IQR were then calculated and presented here. N represents the number of datasets for the specified cohort composition.