Table 4 Overall accuracy of gene signatures in distinct patient populations

All subjects

79 (78–80)

-

2887/31

84 (83–85)

-

3584/37

Pathogen

-

-

-

-

-

-

All Bacterial^a

81 (79–83)

-

951/31

-

-

-

 Burkholderia pseudomallei

90 (85–93)

0.010

45/2

-

-

-

 Escherichia coli

84 (79–89)

0.972

64/7

-

-

-

 Staphylococcus aureus

83 (79–87)

0.972

118/8

-

-

-

 Staphylococcus, other

91 (88–94)

< 0.001

58/4

-

-

-

 Streptococcus pneumoniae

83 (76–89)

0.972

39/6

-

-

-

 Streptococcus, other

82 (75–88)

0.972

43/8

-

-

-

 Intracellular bacteria

83 (79–88)

0.178

100/4

-

-

-

 Extracellular bacteria

84 (81–86)

0.173

415/17

-

-

-

All Viral^a

-

-

-

82 (80–83)

-

1679/37

 Adenovirus

-

-

-

74 (62–84)

0.030

30/2

 Enterovirus

-

-

-

84 (76–89)

0.937

58/3

 Influenza

-

-

-

89 (87–90)

< 0.001

431/19

 Rhinovirus

-

-

-

74 (70–78)

< 0.001

209/9

 RSV

-

-

-

81 (79–84)

0.083

406/13

Age

-

-

-

-

-

-

Adult^a

82 (80–83)

-

1183/18

88 (86–89)

-

1268/14

12–18 years

82 (78–85)

0.299

132/6

88 (84–92)

0.631

95/6

2–11 years

70 (67–73)

< 0.001

373/7

79 (76–82)

< 0.001

352/10

3 months–1 year

73 (69–77)

< 0.001

183/8

80 (78–82)

< 0.001

576/17

<3 months

85 (82–88)

0.002

320/8

81 (79–84)

< 0.001

547/16

Race

-

-

-

-

-

-

All Subjects^a

77 (76–79)

-

1389/12

80 (78–81)

-

1157/12

 Asian

84 (79–89)

0.007

87/9

84 (76–91)

0.277

33/7

 Black

79 (75–82)

0.059

311/11

77 (73–81)

0.277

254/12

 White

76 (73–78)

0.028

684/11

80 (78–82)

0.784

686/12

 Other

71 (64–78)

0.010

72/5

74 (67-82)

0.277

79/6

Ethnicity

-

-

-

-

-

-

Not Hispanic or Latino^a

75 (73–77)

-

407/4

79 (77–81)

-

474/5

Hispanic or Latino

80 (77–84)

< 0.001

302/9

85 (81–88)

< 0.001

220/11

Severity

-

-

-

-

-

-

Non-ICU^a

73 (66–79)

-

43/2

83 (79–86)

-

117/3

ICU

69 (66–73)

0.279

182/8

86 (82–90)

0.105

107/7