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Table 1 Demographic information of the included cohorts

From: A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects

Cohort n AAO Female APOE genotype no. (%)
ϵ2/ϵ2 ϵ2/ϵ3 ϵ2/ϵ4 ϵ3/ϵ3 ϵ3/ϵ4 ϵ4/ϵ4
Mean Range n % n % n % n % n % n % n %
AD 376 59 30-90 249 66.2 - - 15 4 4 1.1 168 45 139 37.1 49 13.1
FTLD-MND 197 58.8 21-82 92 46.7 1 0.5 18 9.1 - - 122 62 49 24.9 7 3.6
EOD 73 54.5 25-75 49 67.1 - - 2 2.7 - - 39 53 20 27.4 12 16.4
Healthy 254 60 18-100a 159 62.6 2 0.8 25 9.8 1 0.4 159 45 61 23.9 4 1.6
  549 60.7 3 0.3 60 6.7 5 0.6 488 54.2 269 29.9 72 8
  1. AD Alzheimer’s disease, FTLD-MND frontotemporal lobar degeneration and motor neuron disorder, EOD early-onset dementia not otherwise specified, AAO age at onset
  2. a Age at evaluation. There were three Individuals with uncalled APOE genotype (one from AD cohort and two healthy individuals)