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Fig. 1 | Genome Medicine

Fig. 1

From: Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

Fig. 1

Colocalization testing narrows candidate genes across cardiometabolic traits, tissues, and QTL types. a Candidate genes are filtered based on GWAS proximity (filter 1), GWAS/QTL overlap (filter 2), and colocalization testing (filter 3). The per-gene filtering process is further described in Additional file 1: Fig. S1. b Scatterplot of the relationship between sample size and number of eQTL/sQTL colocalizations in a given tissue. c Number of loci and number of individual genes with colocalizations for sQTLs, eQTLs, or both. d Scatterplot of the relationship between the number of candidates (number genes with QTL overlapping a lead GWAS variant) and the number of colocalizations at each locus

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