Table 1 Characteristics of participants included in the study

Total

2138^a

502

282

 Male

1132 (53.0)

267 (53.2)

137 (48.6)

0.17

0.19

 Female

1006 (47.0)

235 (46.8)

145 (51.4)

 Hispanic

24 (1.1)

11 (2.2)

6 (2.1)

0.18

0.15

 Non-Hispanic

2114 (98.9)

491 (97.8)

276 (97.9)

 Leukemia

731 (34.2)

176 (35.1)

  Acute lymphoblastic leukemia

671 (31.4)

159 (31.7)

–

  Acute myeloid leukemia

58 (2.7)

15 (3.0)

–

  Other leukemia

2 (0.1)

2 (0.4)

–

 Lymphoma

460 (21.5)

36 (7.2)

  Hodgkin lymphoma

296 (13.8)

11 (2.2)

–

  Non-Hodgkin lymphoma

164 (7.7)

25 (5.0)

–

 Sarcoma

283 (13.2)

39 (7.8)

–

  Ewing sarcoma

76 (3.6)

7 (1.4)

–

  Osteosarcoma

76 (3.6)

5 (1.0)

  Rhabdomyosarcoma

73 (3.4)

15 (3.0)

–

  Nonrhabdomyosarcoma

58 (2.7)

12 (2.4)

–

 CNS tumors

245 (11.5)

83 (16.5)

  Astrocytoma or glioma

113 (5.3)

41 (8.2)

–

  Medulloblastoma or PNET

59 (2.8)

15 (3.0)

–

  Ependymoma

27 (1.3)

8 (1.6)

–

  Other CNS tumors

46 (2.2)

19 (3.8)

–

 Embryonal

285 (13.3)

82 (16.3)

  Wilms tumor

140 (6.5)

32 (6.4)

–

  Neuroblastoma

109 (5.1)

39 (7.8)

–

  Germ cell tumor

36 (1.9)

11 (2.2)

–

 Other

134 (6.3)

86 (17.1)

  Retinoblastoma

50 (2.3)

67 (13.3)

–

  Hepatoblastoma

15 (0.7)

2 (0.4)

–

  Melanoma

13 (0.6)

4 (0.8)

–

  Carcinomas

24 (1.1)

3 (0.6)

–

  Others

32 (1.5)

10 (2.0)

–

 Brain RT

666 (31.2)

147 (29.3)

–

 Chest RT

608 (28.4)

82 (16.3)

–

 Abdomen/pelvis RT

479 (22.4)

81 (16.1)

–

 Alkylating agent

1269 (59.4)

257 (51.2)

–

 Anthracyclines

1265 (59.2)

257 (51.2)

–

 Epipodophyllotoxins

762 (35.6)

166 (33.1)

–

 Glucocorticoids

1010 (47.2)

199 (39.6)

–

 Platinum

271 (12.7)

126 (25.1)

–

 Vincristine

1489 (69.6)

343 (68.3)

–

Median age at diagnosis, years (range)

7.3 (0.0, 23.6)

3.1 (0.0, 19.9)

NA

Median age at DNA sampling, years (range)

31.8 (6.0, 66.4)

16.5 (7.3, 66.6)

35.0 (18.7, 70.2)

<0.001

<0.001