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Table 1 Characteristics of participants included in the study

From: Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer

Characteristics SJLIFE1 survivors
No. (%)
SJLIFE2 survivors
No. (%)
Non-cancer controls
No. (%)
SJLIFE1 vs. SJLIFE2
P
Survivors vs. controls
P
Total 2138a 502 282   
Sex
 Male 1132 (53.0) 267 (53.2) 137 (48.6) 0.17 0.19
 Female 1006 (47.0) 235 (46.8) 145 (51.4)   
Ethnicity
 Hispanic 24 (1.1) 11 (2.2) 6 (2.1) 0.18 0.15
 Non-Hispanic 2114 (98.9) 491 (97.8) 276 (97.9)   
Diagnosis
 Leukemia 731 (34.2) 176 (35.1)    
  Acute lymphoblastic leukemia 671 (31.4) 159 (31.7)   
  Acute myeloid leukemia 58 (2.7) 15 (3.0)   
  Other leukemia 2 (0.1) 2 (0.4)   
 Lymphoma 460 (21.5) 36 (7.2)    
  Hodgkin lymphoma 296 (13.8) 11 (2.2)   
  Non-Hodgkin lymphoma 164 (7.7) 25 (5.0)   
 Sarcoma 283 (13.2) 39 (7.8)   
  Ewing sarcoma 76 (3.6) 7 (1.4)   
  Osteosarcoma 76 (3.6) 5 (1.0)    
  Rhabdomyosarcoma 73 (3.4) 15 (3.0)   
  Nonrhabdomyosarcoma 58 (2.7) 12 (2.4)   
 CNS tumors 245 (11.5) 83 (16.5)    
  Astrocytoma or glioma 113 (5.3) 41 (8.2)   
  Medulloblastoma or PNET 59 (2.8) 15 (3.0)   
  Ependymoma 27 (1.3) 8 (1.6)   
  Other CNS tumors 46 (2.2) 19 (3.8)   
 Embryonal 285 (13.3) 82 (16.3)    
  Wilms tumor 140 (6.5) 32 (6.4)   
  Neuroblastoma 109 (5.1) 39 (7.8)   
  Germ cell tumor 36 (1.9) 11 (2.2)   
 Other 134 (6.3) 86 (17.1)    
  Retinoblastoma 50 (2.3) 67 (13.3)   
  Hepatoblastoma 15 (0.7) 2 (0.4)   
  Melanoma 13 (0.6) 4 (0.8)   
  Carcinomas 24 (1.1) 3 (0.6)   
  Others 32 (1.5) 10 (2.0)   
Radiation
 Brain RT 666 (31.2) 147 (29.3)   
 Chest RT 608 (28.4) 82 (16.3)   
 Abdomen/pelvis RT 479 (22.4) 81 (16.1)   
Chemotherapy
 Alkylating agent 1269 (59.4) 257 (51.2)   
 Anthracyclines 1265 (59.2) 257 (51.2)   
 Epipodophyllotoxins 762 (35.6) 166 (33.1)   
 Glucocorticoids 1010 (47.2) 199 (39.6)   
 Platinum 271 (12.7) 126 (25.1)   
 Vincristine 1489 (69.6) 343 (68.3)   
Median age at diagnosis, years (range) 7.3 (0.0, 23.6) 3.1 (0.0, 19.9) NA   
Median age at DNA sampling, years (range) 31.8 (6.0, 66.4) 16.5 (7.3, 66.6) 35.0 (18.7, 70.2) <0.001 <0.001
  1. Abbreviations: SJLIFE1 survivors The first discovery data set of 2138 survivors included in our previously published study (ref. [6]), SJLIFE2 survivors The second discovery data set of 502 children and adolescent survivors, CNS Central nervous system, PNET Primitive neuroectodermal tumor, RT Radiotherapy
  2. aStarting from 2139 survivors included in our previous publication (ref. [6]), a retinoblastoma survivor failed the minfi QC with low total intensity and hence was excluded from this current analysis