Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer

Table 2 Top SNP significantly associated with EAA-Horvath and EAA-Hannum among survivors (SJLIFE1, SJLIFE2) and controls

GWAS	SNP	Chr	Pos_hg38	Effect allele	Other allele	Population	Effect size	(SE)	P	P_het	I² (%)
EAA-Horvath	rs732314	1	169630016	C	T	SJLIFE1 survivors	0.50	0.10	1.55E−07
						SJLIFE2 survivors	0.82	0.19	2.09E−05
						Combined survivors	0.57	0.09	3.30E−11	0.14	54.36
						Community controls	1.09	0.27	5.43E−05
EAA-Hannum	rs28366133	6	31396299	C	T	SJLIFE1 survivors	0.76	0.14	5.30E−08
						SJLIFE2 survivors	0.84	0.23	2.05E−04
						Combined survivors	0.78	0.12	3.78E−11	0.75	0.00
						Community controls	0.21	0.30	4.88E−01

Abbreviations: GWAS Genome-wide association study, EAA Epigenetic age acceleration, Chr Chromosome, SE Standard error, SJLIFE1 survivors The first discovery data set of 2138 survivors included in our previously published study (ref. [6]), SJLIFE2 survivors The second discovery data set of 502 children and adolescent survivors, Combined survivors A combined set (meta-GWAS analysis) of the two discovery data sets (SJLIFE1 and SJLIFE2), Community controls A set of 282 community controls

ISSN: 1756-994X