|
GWAS
|
SNP
|
Chr
|
Pos_hg38
|
Effect allele
|
Other allele
|
Population
|
Effect size
|
(SE)
|
P
|
Phet
|
I2 (%)
|
|---|
|
EAA-Horvath
|
rs732314
|
1
|
169630016
|
C
|
T
|
SJLIFE1 survivors
|
0.50
|
0.10
|
1.55E−07
| | |
|
SJLIFE2 survivors
|
0.82
|
0.19
|
2.09E−05
| | |
|
Combined survivors
|
0.57
|
0.09
|
3.30E−11
|
0.14
|
54.36
|
|
Community controls
|
1.09
|
0.27
|
5.43E−05
| | |
|
EAA-Hannum
|
rs28366133
|
6
|
31396299
|
C
|
T
|
SJLIFE1 survivors
|
0.76
|
0.14
|
5.30E−08
| | |
|
SJLIFE2 survivors
|
0.84
|
0.23
|
2.05E−04
| | |
|
Combined survivors
|
0.78
|
0.12
|
3.78E−11
|
0.75
|
0.00
|
|
Community controls
|
0.21
|
0.30
|
4.88E−01
| | |
- Abbreviations: GWAS Genome-wide association study, EAA Epigenetic age acceleration, Chr Chromosome, SE Standard error, SJLIFE1 survivors The first discovery data set of 2138 survivors included in our previously published study (ref. [6]), SJLIFE2 survivors The second discovery data set of 502 children and adolescent survivors, Combined survivors A combined set (meta-GWAS analysis) of the two discovery data sets (SJLIFE1 and SJLIFE2), Community controls A set of 282 community controls
