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Table 3 Age-related, gender-, and treatment-stratified effect sizes of significant SNPs associated with EAA among different data sets

From: Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer

GWAS SNP Population Effect size (SE) P Phet I2 (%)
EAA-Horvath rs732314 survivors (SJLIFE1) <18 Y 70 0.96 0.50 6.16E−02   
survivors (SJLIFE2) <18 Y 314 0.97 0.25 1.27E−04   
survivors (combined) <18 Y 384 0.97 0.22 1.52E−05 0.98 0.00
survivors (SJLIFE1) ≥18 Y 2066 0.51 0.10 1.14E−07   
survivors (SJLIFE2) ≥18 Y 188 0.51 0.26 5.04E−02   
survivors (combined) ≥18 Y 2254 0.51 0.09 1.39E−08 1.00 0.00
survivors (SJLIFE1) male 1132 0.46 0.13 3.92E−04   
survivors (SJLIFE2) male 267 0.79 0.25 1.71E−03   
survivors (combined) male 1399 0.53 0.11 3.94E−06 0.24 28.57
survivors (SJLIFE1) female 1004 0.54 0.14 2.10E−04   
survivors (SJLIFE2) female 235 0.84 0.30 5.04E−03   
survivors (combined) female 1239 0.60 0.13 4.58E−06 0.35 0.00
survivors (SJLIFE1) trunk-RT_Yes 649 0.37 0.17 3.47E−02   
survivors (SJLIFE2) trunk-RT_Yes 91 0.03 0.39 9.39E−01   
survivors (combined) trunk-RT_Yes 740 0.31 0.16 4.99E−02 0.42 0.00
survivors (SJLIFE1) trunk-RT_No 1487 0.56 0.12 1.30E−06   
survivors (SJLIFE2) trunk-RT_No 411 0.91 0.22 3.46E−05   
survivors (combined) trunk-RT_No 1898 0.64 0.10 3.88E−10 0.16 49.83
EAA-Hannum rs28366133 survivors (SJLIFE1) <18 Y 70 0.17 0.73 8.20E−01   
survivors (SJLIFE2) <18 Y 314 1.13 0.27 5.17E−05   
survivors (combined) <18 Y 384 1.01 0.26 8.80E−05 0.21 35.12
survivors (SJLIFE1) ≥18 Y 2066 0.80 0.14 2.54E−08   
survivors (SJLIFE2) ≥18 Y 188 0.28 0.40 4.78E−01   
survivors (combined) ≥18 Y 2254 0.74 0.13 3.69E−08 0.23 32.01
survivors (SJLIFE1) male 1131 0.74 0.19 1.40E−04   
survivors (SJLIFE2) male 267 0.91 0.32 4.43E−03   
survivors (combined) male 1398 0.79 0.17 1.97E−06 0.64 0.00
survivors (SJLIFE1) female 1005 0.77 0.20 1.39E−04   
survivors (SJLIFE2) female 235 0.71 0.33 3.47E−02   
survivors (combined) female 1240 0.76 0.17 1.23E−05 0.87 0.00
survivors (SJLIFE1) chest-RT_Yes 608 0.72 0.27 6.89E−03   
survivors (SJLIFE2) chest-RT_Yes 83 0.84 0.71 2.41E−01   
survivors (combined) chest-RT_Yes 691 0.74 0.25 3.14E−03 0.88 0.00
survivors (SJLIFE1) chest-RT_No 1528 0.77 0.16 2.48E−06   
survivors (SJLIFE2) chest-RT_No 419 0.88 0.24 3.02E−04   
survivors (combined) chest-RT_No 1947 0.80 0.14 2.56E−09 0.70 0.00
  1. Abbreviations: GWAS Genome-wide association study, EAA Epigenetic age acceleration, Chr Chromosome, SE Standard error, N Number of samples, survivor (SJLIFE1) The first discovery data set of 2138 survivors included in our previously published study (ref. [6]), survivor (SJLIFE2) The second discovery data set of 502 children and adolescent survivors, survivors (combined) A combined set (meta-GWAS analysis) of the two discovery data sets (SJLIFE1 and SJLIFE2), trunk-RT Chest/abdominal/pelvic radiation therapy, chest-RT Chest radiation therapy