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Table 1 Results for gene ontology (GO) analysis for the MWAS on PRS at pT 5 × 10−8. Analyses were conducted separately for including and excluding the MHC region. Top ten GO terms are listed in the table. BP=biological process, CC=cellular component and MF=molecular function

From: DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

  GO ID Ontology Term N DE PDE PFDR
With MHC region GO:0072643 BP Interferon-gamma secretion 22 2 2.24E−04 1
GO:0003050 BP Regulation of systemic arterial blood pressure by atrial natriuretic peptide 2 1 2.64E−03 1
GO:0021691 BP Cerebellar Purkinje cell layer maturation 2 1 3.27E−03 1
GO:0021590 BP Cerebellum maturation 3 1 3.64E−03 1
GO:0021699 BP Cerebellar cortex maturation 3 1 3.64E−03 1
GO:1902412 BP Regulation of mitotic cytokinesis 6 1 3.88E−03 1
GO:0032609 BP Interferon-gamma production 105 2 4.06E−03 1
GO:0072686 CC Mitotic spindle 103 2 4.94E−03 1
GO:0046340 BP Diacylglycerol catabolic process 4 1 5.24E−03 1
GO:0048408 MF Epidermal growth factor binding 4 1 5.99E−03 1
Without MHC region GO:0072686 CC Mitotic spindle 101 2 2.14E−03 1
GO:0003050 BP Regulation of systemic arterial blood pressure by atrial natriuretic peptide 2 1 2.30E−03 1
GO:1902412 BP Regulation of mitotic cytokinesis 6 1 2.31E−03 1
GO:0021691 BP Cerebellar Purkinje cell layer maturation 2 1 2.45E−03 1
GO:0021590 BP Cerebellum maturation 3 1 2.56E−03 1
GO:0021699 BP Cerebellar cortex maturation 3 1 2.56E−03 1
GO:0046340 BP Diacylglycerol catabolic process 4 1 4.06E−03 1
GO:0051315 BP Attachment of mitotic spindle microtubules to kinetochore 13 1 4.23E−03 1
GO:0021578 BP Hindbrain maturation 6 1 4.40E−03 1
GO:0021626 BP Central nervous system maturation 7 1 4.51E−03 1