Skip to main content

Table 2 Results for pathway analysis for the MWAS on PRS at pT 5 × 10−8. Analyses were conducted separately for including and excluding the MHC region. Top ten Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways are listed in the table

From: DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

  KEGG pathway ID Description N DE P PFDR
With MHC region path:hsa05322 Systemic lupus erythematosus 112 1.5 0.093896415 1
path:hsa04914 Progesterone-mediated oocyte maturation 88 1 0.10085395 1
path:hsa04110 Cell cycle 123 1 0.110965189 1
path:hsa04217 Necroptosis 147 1 0.116705111 1
path:hsa04114 Oocyte meiosis 117 1 0.118584815 1
path:hsa04925 Aldosterone synthesis and secretion 95 1 0.137824504 1
path:hsa04613 Neutrophil extracellular trap formation 159 1.5 0.148531242 1
path:hsa04514 Cell adhesion molecules 136 1 0.156764027 1
path:hsa04723 Retrograde endocannabinoid signalling 134 1 0.157693357 1
path:hsa05034 Alcoholism 163 1.5 0.162889755 1
Without MHC region path:hsa04914 Progesterone-mediated oocyte maturation 88 1 0.077051 1
path:hsa04110 Cell cycle 123 1 0.079099 1
path:hsa04114 Oocyte meiosis 116 1 0.082834 1
path:hsa04514 Cell adhesion molecules 118 1 0.098456 1
path:hsa04925 Aldosterone synthesis and secretion 92 1 0.104019 1
path:hsa04723 Retrograde endocannabinoid signalling 133 1 0.113819 1
path:hsa05203 Viral carcinogenesis 152 1 0.127128 1
path:hsa05166 Human T-cell leukaemia virus 1 infection 193 1 0.1555 1
path:hsa04662 B cell receptor signalling pathway 76 0 1 1
path:hsa05224 Breast cancer 143 0 1 1