Fig. 1

Framework for estimating mutation rates of < 1 Mb LOF CNVs per gene. a A conceptional overview showing the method for calculating the mutation rates of < 1 Mb LOF dnCNVs per gene. b A scheme depicting the method for selecting training genes. We selected training genes (here, the gene in red) that are LOF-tolerant and flanked by upstream and downstream > 1 Mb regions without any LOF-intolerant genes