Fig. 3

Spatiotemporal expression patterns of the 328 known and 34 plausible candidate genes. a Enrichment analyses of genes specifically expressed in each brain region at each developmental stage in the 328 known (the six columns of large hexagons) and 34 plausible new genes (columns of small hexagons on the right of the columns of large hexagons). Sizes of the hexagons for the 328 genes correlate with their gene set sizes. The red colors correspond to q-values of Fisher’s exact tests adjusted by the BH method. The regions of the hexagons for the 328 genes closer to the center of each hexagon correspond to genes with smaller pSI scores, namely, increasing specificity (< 0.05, < 0.01, < 0.001, and < 0.0001, respectively), while the hexagons for the 34 genes correspond to genes with pSI scores < 0.05. b Enrichment analyses of genes of each co-expression module in the 328 known (the upper row) and 34 plausible candidate genes (the lower row). The circle colors correspond to q-values of hypergeometric tests adjusted by the BH method. The circle sizes indicate the ratio of each module proportion in the 328 or 34 genes relative to that in all genes