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Fig. 4 | Genome Medicine

Fig. 4

From: Large-scale discovery of novel neurodevelopmental disorder-related genes through a unified analysis of single-nucleotide and copy number variants

Fig. 4

GO terms enriched in the 328 known and 34 plausible candidate genes. a Clusters of GO terms enriched (q-value < 0.01) in the 328 known and 34 plausible candidate genes. Only clusters of ten or more nodes are shown. Each node represents a GO term. Nodes are connected by an edge when the Jaccard and overlap combined coefficient for their gene members is > 0.5. Node size represents the number of gene members. Nodes are colored red when the nodes are statistically significant in the 34 plausible candidate genes. Gray ovals represent manually annotated GO groups. b Histograms of numbers of GO terms enriched (q-value < 0.01) in 34 randomly selected genes. This simulation was repeated 1000 times. In each simulation, only the 1086 terms enriched in the 328 known genes (Additional file 2: Table S13) were analyzed. Red bars indicate the number of GO terms enriched in the 34 plausible candidate genes. Empirical p-values of the enrichment in the 34 genes are the proportion of simulations with a number of GO terms equal to or more than that of the red bars. BP, GO biological process terms; CC, GO cellular component terms; MF, GO molecular function terms

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