Fig. 5
Age-associated memory-like CD52+ NK2 cells (NK2.1) exhibit proinflammatory characteristics and display a type I IFN response state. A Representative flow cytometry analysis of the percentage of NK2.1 cells within NK2 cells (Lin−CD7+NKG2C+CD122low) from young (left) and elderly (right) individuals. B Bar graphs showing the proportion of NK2.1 cells among NK cells (left) and among lymphocytes (right) from young (n = 35) and elderly (n = 27) individuals. C Representative density plots showing the expression of IFN-γ in NK2.1 cells from young and elderly individuals with or without IFN-α stimulation in vitro. D Bar graphs displaying the frequencies of IFN-γ+ cells in NK2.1 cells from young (n = 13) and elderly (n = 12) individuals with or without IFN-α stimulation in vitro. E Representative density plots showing the expression of CD107a in NK2.1 cells from young and elderly individuals with or without IFN-α stimulation in vitro. F Bar graphs displaying the frequencies of CD107a+ cells in NK2.1 cells from young (n = 7) and elderly (n = 7) individuals with or without IFN-α stimulation in vitro