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Fig. 5 | Genome Medicine

Fig. 5

From: Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response

Fig. 5

Non-tumor-associated human dura and meningioma tumor samples show distinctively different immune cell populations. A UMAP visualization of dura and tumor immune cells identified by cell type. B UMAP visualization of dura and tumor monocyte/macrophage/DCs identified by cell type. C UMAP visualization of dura and tumor monocyte/macrophages identified by cell type. D UMAP visualization of select border-associated macrophage (BAM) gene markers and aggregated score. E UMAP visualization of select microglial gene markers and aggregated score. F Violin plots of M1, M2a, M2b, and M2c macrophage polarization state scores of each cluster from Fig. 5C. G Expression heatmap of the top 15 genes of the top 10 principal components with hierarchical clustering and associated functional enrichment analysis of gene clusters. H UMAP visualization of dura and tumor DCs identified by cell type. I Expression heatmap of the top 15 genes of the top 10 principal components with hierarchical clustering and associated functional enrichment analysis of gene clusters

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Genome Medicine

ISSN: 1756-994X

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