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Table 2 Results of replication meta-analysis

From: Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region

Group

CS

Variant

Allele (non-risk/risk)

p-value

OR

95% CI

COA

Class I CS1

rs2428494

T/A

9.72 × 10−04

1.13

1.05–1.21

Class I CS2

HLA-C p.11

Ser/Ala

2.66 × 10−03

1.16

1.05–1.29

Class II CS1

rs28407950

T/C

1.30 × 10−09

1.29

1.19–1.40

Class II CS2

rs35571244

T/C

2.74 × 10−01

1.08

0.94–1.25

AOA

Class I CS1

rs2428494

T/A

1.27 × 10−02

1.06

1.01–1.12

Class II CS1

rs9274660

A/G

6.10 × 10−08

1.14

1.09–1.20

rs3828789

G/T

4.59 × 10−08

1.15

1.09–1.20

rs1063355

T/G

4.31 × 10−08

1.15

1.09–1.20

rs9272346

G/A

7.52 × 10−08

1.14

1.09–1.20

Class II CS2

HLA-DQA1

*03:01

1.27 × 10−04

1.13

1.06–1.21

  1. P-values, odds ratios (ORs), and 95% confidence intervals (95% CI) in the replication cohorts are reported for each of the candidate variants from the discovery COA and AOA credible sets